ABSTRACT
Objective@#To analyze the clinical epidemiological situation and trend of brucellosis in Shanxi Province in order to provide the basis for diagnosis.@*Methods@#Brucellosis cases admitted to the First Hospital of Shanxi Medical University during January 2013 to December 2015 were included in the study. A retrospective investigation was undertaken and patient files were reviewed for general situation, clinical and laboratory findings, the process of diagnosis and treatments.@*Results@#The data of 141 patients were collected, including 100 males and 41 females, the male to female ratio was 2.44 ∶ 1.00; the majority were 51-60 years old, 49 cases, accounting for 34.75%; the peak incidence was July and August each year, a total of 51 cases, accounting for 36.17%; of the 141 patients, 112 (79.43%) were professional, 29 (20.57%) were non-professional; and the clinical performance was diverse, 114 (80.85%) patients with irregular heat type, only 17 cases (12.06%) showed typical migratory joint pain; 31 cases (21.99%) were first diagnosed with only brucellosis, the shortest misdiagnosis time was 1 week, and the longest 18 month, the average misdiagnosis time was 3 months, and the total misdiagnosis rate was as high as 78.01% (110/141).@*Conclusions@#Significant changes have happened in the clinical epidemiological characteristics of brucellosis in Shanxi Province. Various forms of prevention knowledge propaganda and education should be continually carried out, so as to strengthen the awareness and attention of the clinical workers on the disease.
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High mobility group protein B1 (HMGB1) is encoded by HMGB1 gene and is a highly conserved non-histone chromosomal binding protein widely present in the nucleus. It plays an important role in DNA replication and repair of eukaryotic cells. As a delayed inflammatory mediator, HMGB1 secreted or released extracellularly mediates inflammatory response in sepsis, autoimmune diseases, malignant tumors, liver-related diseases, and so on. In recent years, the studies of HMGB1 gene polymorphism have provided a theoretical basis for further clarifying the pathogenesis of diseases. These studies provided early predictions of disease susceptibility for early intervention and provided the basis for precise prevention and treatment of diseases. In this paper, the correlation between HMGB1 and clinical disease susceptibility and prognosis was reviewed.
ABSTRACT
Objective To analyze the clinical epidemiological situation and trend of brucellosis in Shanxi Province in order to provide the basis for diagnosis. Methods Brucellosis cases admitted to the First Hospital of Shanxi Medical University during January 2013 to December 2015 were included in the study. A retrospective investigation was undertaken and patient files were reviewed for general situation, clinical and laboratory findings, the process of diagnosis and treatments. Results The data of 141 patients were collected, including 100 males and 41 females, the male to female ratio was 2.44 : 1.00; the majority were 51 - 60 years old, 49 cases, accounting for 34.75％; the peak incidence was July and August each year, a total of 51 cases, accounting for 36.17％; of the 141 patients, 112 (79.43％) were professional, 29 (20.57％ ) were non -professional; and the clinical performance was diverse, 114 (80.85％) patients with irregular heat type, only 17 cases (12.06％) showed typical migratory joint pain; 31 cases (21.99％) were first diagnosed with only brucellosis, the shortest misdiagnosis time was 1 week, and the longest 18 month, the average misdiagnosis time was 3 months, and the total misdiagnosis rate was as high as 78.01％ (110/141). Conclusions Significant changes have happened in the clinical epidemiological characteristics of brucellosis in Shanxi Province. Various forms of prevention knowledge propaganda and education should be continually carried out, so as to strengthen the awareness and attention of the clinical workers on the disease.
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Objective To reveal the epidemiological characterization of brucellosis in Shanxi province in recent years.Methods Retrospective investigation was made from the 105 diagnosed brucellosis cases in the first hospital affiliated to Shanxi medical university during 2013.1 ~2015.3.Results Peasants accounted for 89.52%and urban residents was 10.48% in 105 cases;male was the majority.Most cases were seen in late summer and early autumn.88.57% of the cases had clear history of epidemiology,and only 16.85% of those who got close contact with livestock took uncomplicated preventive measures.Conclusion Transmission mode of brucellosis has greatly changed in Shanxi province in recent years.Infected cases have increased year by year,and incidence ratio in urban residents is rising.Extensive breakout is replacing by fragmented scattering point.
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OBJECTIVE To characterize the relationship between promoter of FGL2 gene(site-1285T/A)polymorphism and clinical subgroups infected with HBV. METHODS The genotype was analyzed by using method of polymerase chain reaction(PCR),enzyme restriction after PCR amplification,and agarose gel electrophoresis.Statistics were used ?~2 and Logistic regression. RESULTS There were no statistic genotype or allele frequency differences between any two subgroups(except acute hepatitis B and liver cancer). CONCLUSIONS Promoter of fgl2 gene(site1285T/A) polymorphism has no relation with HBV infection.